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The aryl hydrocarbon receptor: A predominant mediator for the toxicity of emerging dioxin-like compounds
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SYSNO ASEP 0559979 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The aryl hydrocarbon receptor: A predominant mediator for the toxicity of emerging dioxin-like compounds Tvůrce(i) Zhang, W. (CN)
Xie, H. Q. (CN)
Li, Y. (CN)
Zhou, Ming-Xi (BC-A) RID, ORCID
Zhou, Z. (CN)
Wang, R. (CN)
Hahn, M. E. (US)
Zhao, B. (US)Celkový počet autorů 8 Číslo článku 128084 Zdroj.dok. Journal of Hazardous Materials. - : Elsevier - ISSN 0304-3894
Roč. 426, March 15 (2022)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Aryl hydrocarbon receptor ; AHR ligands ; Dioxin-like compounds ; Molecular mechanisms ; Toxicity evaluation Vědní obor RIV EF - Botanika Obor OECD Plant sciences, botany Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000752476800005 EID SCOPUS 85121447616 DOI https://doi.org/10.1016/j.jhazmat.2021.128084 Anotace The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) family of transcription factors and has broad biological functions. Early after the identification of the AHR, most studies focused on its roles in regulating the expression of drug-metabolizing enzymes and mediating the toxicity of dioxins and dioxin-like compounds (DLCs). Currently, more diverse functions of AHR have been identified, indicating that AHR is not just a dioxin receptor. Dioxins and DLCs occur ubiquitously and have diverse health/ ecological risks. Additional research is required to identify both shared and compound-specific mechanisms, especially for emerging DLCs such as polyhalogenated carbazoles (PHCZs), polychlorinated diphenyl sulfides (PCDPSs), and others, of which only a few investigations have been performed at present. Many of the toxic effects of emerging DLCs were observed to be predominantly mediated by the AHR because of their structural similarity as dioxins, and the in vitro TCDD-relative potencies of certain emerging DLC congeners are comparable to or even greater than the WHO-TEFs of OctaCDD, OctaCDF, and most coplanar PCBs. Due to the close relationship between AHR biology and environmental science, this review begins by providing novel insights into AHR signaling (canonical and non-canonical), AHR's biochemical properties (AHR structure, AHR-ligand interaction, AHR-DNA binding), and the variations during AHR transactivation. Then, AHR ligand classification and the corresponding mechanisms are discussed, especially the shared and compound-specific, AHR-mediated effects and mechanisms of emerging DLCs. Accordingly, a series of in vivo and in vitro toxicity evaluation methods based on the AHR signaling pathway are reviewed. In light of current advances, future research on traditional and emerging DLCs will enhance our understanding of their mechanisms, toxicity, potency, and ecological impacts. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0304389421030533?via%3Dihub
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