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Anatomy-dependent lung doses from 3D-conformal breast-cancer radiotherapy
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SYSNO ASEP 0559073 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Anatomy-dependent lung doses from 3D-conformal breast-cancer radiotherapy Tvůrce(i) Kundrát, Pavel (UJF-V) RID, ORCID, SAI
Rennau, H. (DE)
Remmele, J. (DE)
Sebb, S. (DE)
Simonetto, C. (DE)
Kaiser, J. (DE)
Hildebrandt, G. (DE)
Wolf, U. (DE)
Eidemuller, M. (DE)Celkový počet autorů 9 Číslo článku 10909 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 12, č. 1 (2022)Poč.str. 9 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova breast-cancer ; radiotherapy ; 3D-conformal Obor OECD Radiology, nuclear medicine and medical imaging Způsob publikování Open access Institucionální podpora UJF-V - RVO:61389005 UT WOS 000819039200002 EID SCOPUS 85132971721 DOI 10.1038/s41598-022-14149-2 Anotace This study aims to identify key anatomic features that govern the individual variability of lung doses from breast-cancer radiotherapy. 3D conformal, intensity-modulated and hybrid techniques with 50.4 Gy whole-breast dose were planned for 128 patients. From their CT images, 17 anatomic measures were assessed and tested as predictors for lung dose-volume characteristics. Tangential techniques yielded mean ipsilateral lung doses in the range of 3-11 Gy. This inter-patient variability was explained to almost 40% by central lung distance, and to almost 60% if this measure was complemented by midplane lung width and maximum heart distance. Also the variability in further dose-volume metrics such as volume fractions receiving 5, 20 or 40 Gy could be largely explained by the anatomy. Multi-field intensity-modulated radiotherapy reduced high-exposed lung volumes, but resulted in higher mean ipsilateral lung doses and larger low-dose burden. Contralateral lung doses ranged from 0.3 to 1 Gy. The results highlight that there are large differences in lung doses among breast-cancer patients. Most of this inter-individual variability can be explained by a few anatomic features. The results will be implemented in a dedicated software tool to provide personalized estimates of long-term health risks related to breast-cancer radiotherapy. The results may also be used to identify favourable as well as problematic anatomies, and serve as a quick quantitative benchmark for individual treatment plans. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2023 Elektronická adresa https://doi.org/10.1038/s41598-022-14149-2
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