Počet záznamů: 1
Obesity II: Establishing causal links between chemical exposures and obesity
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SYSNO ASEP 0558379 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Obesity II: Establishing causal links between chemical exposures and obesity Tvůrce(i) Heindel, J. J. (US)
Howard, S. (US)
Agay-Shay, K. (FR)
Arrebola, J. (FR)
Audouze, K. (FR)
Babin, P. (US)
Barouki, R. (US)
Bansal, A. (FR)
Blanc, E. (US)
Cave, M. (US)
Chatterjee, S. (IT)
Chevalier, N. (US)
Choudhury, M. (IE)
Collier, D. (GB)
Connolly, L. (IL)
Coumoul, X. (FR)
Garruti, G. (ES)
Gilbertson, M. (AU)
Hoepner, L. (US)
Holloway, A. K. (US)
Howell Iii, G. (US)
Kassotis, C. (US)
Kay, M. (US)
Kim, M. (US)
Lagadic-Gossmann, D. (FR)
Langouet, S. (FR)
Legrand, A. (FR)
Li, Z. (US)
Le Mentec, H. (FR)
Lind, A. L. (US)
Vondráček, Jan (BFU-R) RID, ORCIDCelkový počet autorů 43 Číslo článku 115015 Zdroj.dok. Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 199, MAY 2022 (2022)Poč.str. 49 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova endocrine-disrupting chemicals ; persistent organic pollutants ; ambient air-pollution ; organophosphate flame-retardants ; activated-receptor-gamma ; aryl-hydrocarbon receptor Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy CEP GA21-00533S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000800429000001 EID SCOPUS 85129395591 DOI https://doi.org/10.1016/j.bcp.2022.115015 Anotace Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0006295222001095?via%3Dihub
Počet záznamů: 1