Počet záznamů: 1
Regulation of choroid plexus development and its functions
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SYSNO ASEP 0557782 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Regulation of choroid plexus development and its functions Tvůrce(i) Kompanikova, P. (CZ)
Bryja, Vítězslav (BFU-R) RID, ORCIDCelkový počet autorů 2 Číslo článku 304 Zdroj.dok. Cellular and Molecular Life Sciences - ISSN 1420-682X
Roč. 79, č. 6 (2022)Poč.str. 15 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova endothelial growth-factor ; roof plate ; sonic hedgehog ; rhombic lip ; cell-proliferation ; lateral ventricle ; epithelial-cells ; cerebral-cortex Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 000797791300005 EID SCOPUS 85130317221 DOI https://doi.org/10.1007/s00018-022-04314-1 Anotace The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the central nervous system (CNS), most notably the production of cerebrospinal fluid (CSF). The epithelial cells of the ChP have the competence to tightly modulate the biomolecule composition of CSF, which acts as a milieu functionally connecting ChP with other brain structures. This review aims to eloquently summarize the current knowledge about the development of ChP. We describe the mechanisms that control its early specification from roof plate followed by the formation of proliferative regions-cortical hem and rhombic lips-feeding later development of ChP. Next, we summarized the current knowledge on the maturation of ChP and mechanisms that control its morphological and cellular diversity. Furthermore, we attempted to review the currently available battery of molecular markers and mouse strains available for the research of ChP, and identified some technological shortcomings that must be overcome to accelerate the ChP research field. Overall, the central principle of this review is to highlight ChP as an intriguing and surprisingly poorly known structure that is vital for the development and function of the whole CNS. We believe that our summary will increase the interest in further studies of ChP that aim to describe the molecular and cellular principles guiding the development and function of this tissue. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2023 Elektronická adresa https://link.springer.com/article/10.1007/s00018-022-04314-1
Počet záznamů: 1