Počet záznamů: 1
A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis
- 1.
SYSNO ASEP 0556315 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A numerical algorithm for modeling cellular rearrangements in tissue morphogenesis Tvůrce(i) Mohammad, R. Z. (JP)
Murakawa, H. (JP)
Švadlenka, Karel (MU-W) RID, SAI
Togashi, H. (JP)Číslo článku 239 Zdroj.dok. Communications Biology. - : Nature Publishing Group
Roč. 5, č. 1 (2022)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cell selection ; epithelium ; histogenesis ; mathematical model Vědní obor RIV BA - Obecná matematika Obor OECD Pure mathematics Způsob publikování Open access Institucionální podpora MU-W - RVO:67985840 UT WOS 000770660100001 EID SCOPUS 85126670500 DOI 10.1038/s42003-022-03174-6 Anotace Among morphological phenomena, cellular patterns in developing sensory epithelia have gained attention in recent years. Although physical models for cellular rearrangements are well-established thanks to a large bulk of experimental work, their computational implementation lacks solid mathematical background and involves experimentally unreachable parameters. Here we introduce a level set-based computational framework as a tool to rigorously investigate evolving cellular patterns, and study its mathematical and computational properties. We illustrate that a compelling feature of the method is its ability to correctly handle complex topology changes, including frequent cell intercalations. Combining this accurate numerical scheme with an established mathematical model, we show that the proposed framework features minimum possible number of parameters and is capable of reproducing a wide range of tissue morphological phenomena, such as cell sorting, engulfment or internalization. In particular, thanks to precise mathematical treatment of cellular intercalations, this method succeeds in simulating experimentally observed development of cellular mosaic patterns in sensory epithelia. Pracoviště Matematický ústav Kontakt Jarmila Štruncová, struncova@math.cas.cz, library@math.cas.cz, Tel.: 222 090 757 Rok sběru 2023 Elektronická adresa https://doi.org/10.1038/s42003-022-03174-6
Počet záznamů: 1