Počet záznamů: 1
Right versus left ventricular remodeling in heart failure due to chronic volume overload
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SYSNO ASEP 0554631 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Right versus left ventricular remodeling in heart failure due to chronic volume overload Tvůrce(i) Havlenová, T. (CZ)
Škaroupková, P. (CZ)
Miklovic, M. (CZ)
Behounek, M. (CZ)
Chmel, M. (CZ)
Jarkovská, D. (CZ)
Švíglerová, J. (CZ)
Štengl, M. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Novotný, Jiří (UMG-J) ORCID
Beneš, J. (CZ)
Červenka, L. (CZ)
Petrák, J. (CZ)
Melenovský, V. (CZ)Celkový počet autorů 14 Číslo článku 17136 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 11, č. 1 (2021)Poč.str. 16 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova myosin heavy-chain ; pulmonary-hypertension ; extracellular-matrix ; molecular-mechanisms ; loading conditions ; gene-expression ; cell-adhesion ; rats ; dysfunction ; model Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology CEP LM2018131 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Výzkumná infrastruktura ELIXIR-CZ II - 90131 - Ústav organické chemie a biochemie AV ČR, v. v. i. Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000691025800018 DOI 10.1038/s41598-021-96618-8 Anotace Mechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identify interventricular differences in response to chronic VO. Rats underwent aorto-caval fistula (ACF)/sham operation to induce VO. After 24 weeks, RV and left ventricular (LV) functions, gene expression and proteomics were studied. ACF led to biventricular dilatation, systolic dysfunction and hypertrophy affecting relatively more RV. Increased RV afterload contributed to larger RV stroke work increment compared to LV. Both ACF ventricles displayed upregulation of genes of myocardial stress and metabolism. Most proteins reacted to VO in a similar direction in both ventricles, yet the expression changes were more pronounced in RV (p(slope): < 0.001). The most upregulated were extracellular matrix (POSTN, NRAP, TGM2, CKAP4), cell adhesion (NCAM, NRAP, XIRP2) and cytoskeletal proteins (FHL1, CSRP3) and enzymes of carbohydrate (PKM) or norepinephrine (MAOA) metabolism. Downregulated were MYH6 and FAO enzymes. Therefore, when exposed to identical VO, both ventricles display similar upregulation of stress and metabolic markers. Relatively larger response of ACF RV compared to the LV may be caused by concomitant pulmonary hypertension. No evidence supports RV chamber-specific regulation of protein expression in response to VO. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2022 Elektronická adresa https://www.nature.com/articles/s41598-021-96618-8
Počet záznamů: 1