Počet záznamů: 1
Kill&repel coatings: the marriage of antifouling and bactericidal properties to mitigate and treat wound infections
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SYSNO ASEP 0554521 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Kill&repel coatings: the marriage of antifouling and bactericidal properties to mitigate and treat wound infections Tvůrce(i) Garay-Sarmiento, M. (DE)
Witzdam, L. (DE)
Vorobii, M. (DE)
Simons, C. (DE)
Herrmann, N. (DE)
de los Santos Pereira, Andres (UMCH-V) RID, ORCID
Heine, E. (DE)
El-Awaad, I. (DE)
Lütticken, R. (DE)
Jakob, F. (DE)
Schwaneberg, U. (DE)
Rodriguez-Emmenegger, C. (DE)Číslo článku 2106656 Zdroj.dok. Advanced Functional Materials - ISSN 1616-301X
Roč. 32, č. 9 (2022)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova antifouling ; bactericidal ; endolysin Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000709160800001 EID SCOPUS 85117376027 DOI 10.1002/adfm.202106656 Anotace Wound infections originate when exogenous or endogenous bacterial pathogens can circumvent the barrier of the wound dressing and invade the wound bed. Bacterial colonization causes inflammation, stalls the healing process, and carries the risk of dissemination to other tissues. In addition, current antimicrobial dressings fail to resolve an infection once it has been established because debris of the killed bacteria rapidly accumulates on their surface and hampers the antimicrobial action. Faced with this challenge, hybrid synthetic-natural water-soluble macromolecules are designed that self-assemble onto the surface of dressings to generate an antifouling brush functionalized with endolysin, a bactericidal enzyme that poses no harm for eukaryotic cells. The simultaneous action of the brush and the enzyme not only prevents the colonization of the dressing, but also enables the coating to kill planktonic bacteria with even higher efficiency than the free enzyme. Remarkably, the Kill&Repel coating could completely eradicate bacteria in a simulated infection without allowing the adhesion of residues on the surface. Thus, this strategy opens a revolutionary approach for protecting and treating an infected wound in a safer and more efficient manner.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/adfm.202106656
Počet záznamů: 1