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Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering
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SYSNO ASEP 0553277 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering Tvůrce(i) Nirwan, V.P. (DE)
Filová, Eva (UEM-P) RID, ORCID
Al-Kattan, A. (FR)
Kabashin, A.V. (FR)
Fahmi, A. (DE)Číslo článku 519 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 11, č. 2 (2021)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova electrospinning ; pulsed laser ablation in liquids ; nanofibers ; polycaprolactone (PCL) ; TiN nanoparticles ; theranostics ; biocompatibility ; scaffold for tissue engineering Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biomaterials (as related to medical implants, devices, sensors) CEP LO1508 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000622932100001 EID SCOPUS 85101477038 DOI 10.3390/nano11020519 Anotace Herein, we report the fabrication and characterization of novel polycaprolactone (PCL)-based nanofibers functionalized with bare (ligand-free) titanium nitride (TiN) nanoparticles (NPs) for tissue engineering applications. Nanofibers were prepared by a newly developed protocol based on the electrospinning of PCL solutions together with TiN NPs synthesized by femtosecond laser ablation in acetone. The generated hybrid nanofibers were characterised using spectroscopy, microscopy, and thermal analysis techniques. As shown by scanning electron microscopy measurements, the fabricated electrospun nanofibers had uniform morphology, while their diameter varied between 0.403 +/- 0.230 mu m and 1.1 +/- 0.15 mu m by optimising electrospinning solutions and parameters. Thermal analysis measurements demonstrated that the inclusion of TiN NPs in nanofibers led to slight variation in mass degradation initiation and phase change behaviour (T-m). In vitro viability tests using the incubation of 3T3 fibroblast cells in a nanofiber-based matrix did not reveal any adverse effects, confirming the biocompatibility of hybrid nanofiber structures. The generated hybrid nanofibers functionalized with plasmonic TiN NPs are promising for the development of smart scaffold for tissue engineering platforms and open up new avenues for theranostic applications. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2079-4991/11/2/519
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