Počet záznamů: 1
The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage
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SYSNO ASEP 0552886 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage Tvůrce(i) Fábik, Jaroslav (UEM-P)
Psutková, Viktorie (UEM-P)
Machoň, Ondřej (UEM-P)Číslo článku 7529 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI - ISSN 1661-6596
Roč. 22, č. 14 (2021)Poč.str. 34 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova neural crest cells ; craniofacial development ; pharyngeal arches ; jaw development Obor OECD Developmental biology Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000677342000001 EID SCOPUS 85110746379 DOI https://doi.org/10.3390/ijms22147529 Anotace The mandibular and hyoid arches collectively make up the facial skeleton, also known as the viscerocranium. Although all three germ layers come together to assemble the pharyngeal arches, the majority of tissue within viscerocranial skeletal components differentiates from the neural crest. Since nearly one third of all birth defects in humans affect the craniofacial region, it is important to understand how signalling pathways and transcription factors govern the embryogenesis and skeletogenesis of the viscerocranium. This review focuses on mouse and zebrafish models of craniofacial development. We highlight gene regulatory networks directing the patterning and osteochondrogenesis of the mandibular and hyoid arches that are actually conserved among all gnathostomes. The first part of this review describes the anatomy and development of mandibular and hyoid arches in both species. The second part analyses cell signalling and transcription factors that ensure the specificity of individual structures along the anatomical axes. The third part discusses the genes and molecules that control the formation of bone and cartilage within mandibular and hyoid arches and how dysregulation of molecular signalling influences the development of skeletal components of the viscerocranium. In conclusion, we notice that mandibular malformations in humans and mice often co-occur with hyoid malformations and pinpoint the similar molecular machinery controlling the development of mandibular and hyoid arches. Pracoviště Ústav experimentální medicíny Kontakt Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/1422-0067/22/14/7529
Počet záznamů: 1