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Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer
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SYSNO ASEP 0551871 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer Tvůrce(i) Bendová, Petra (UEM-P)
Pardini, B. (IT)
Susová, S. (CZ)
Rosendorf, J. (CZ)
Levý, M. (CZ)
Skrobanek, P. (CZ)
Buchler, T. (CZ)
Král, J. (CZ)
Liška, V. (CZ)
Vodičková, Ludmila (UEM-P) RID
Landi, S. (IT)
Souček, P. (CZ)
Naccarati, A. (IT)
Vodička, Pavel (UEM-P) RID
Vymetálková, Veronika (UEM-P) RIDZdroj.dok. Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 42, č. 3 (2021), s. 378-394Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova excision-repair genes ; pancreatic-cancer ; ABC transporters ; prostate-cancer ; target sites ; polymorphisms Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Genetics and heredity (medical genetics to be 3) CEP GA18-09709S GA ČR - Grantová agentura ČR NV17-30920A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000648928600005 EID SCOPUS 85105689482 DOI 10.1093/carcin/bgaa136 Anotace One of the principal mechanisms of chemotherapy resistance in highly frequent solid tumors, such as colorectal cancer (CRC), is the decreased activity of drug transport into tumor cells due to low expression of important membrane proteins, such as solute carrier (SLC) transporters. Sequence complementarity is a major determinant for target gene recognition by microRNAs (miRNAs). Single-nucleotide polymorphisms (SNPs) in target sequences transcribed into messenger RNA may therefore alter miRNA binding to these regions by either creating a new site or destroying an existing one. miRSNPs may explain the modulation of expression levels in association with increased/decreased susceptibility to common diseases as well as in chemoresistance and the consequent inter-individual variability in drug response. In the present study, we investigated whether miRSNPs in SLC transporter genes may modulate CRC susceptibility and patient's survival. Using an in silico approach for functional predictions, we analyzed 26 miRSNPs in 9 SLC genes in a cohort of 1368 CRC cases and 698 controls from the Czech Republic. After correcting for multiple tests, we found several miRSNPs significantly associated with patient's survival. SNPs in SLCO3A1, SLC22A2 and SLC22A3 genes were defined as prognostic factors in the classification and regression tree analysis. In contrast, we did not observe any significant association between miRSNPs and CRC risk. To the best of our knowledge, this is the first study investigating miRSNPs potentially affecting miRNA binding to SLC transporter genes and their impact on CRC susceptibility or patient's prognosis. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2022 Elektronická adresa https://academic.oup.com/carcin/article-abstract/42/3/378/6034128?redirectedFrom=fulltext
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