Počet záznamů: 1  

Cholinergic transmission from the basal forebrain modulates social memory in male mice

  1. 1.
    SYSNO ASEP0546484
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevCholinergic transmission from the basal forebrain modulates social memory in male mice
    Tvůrce(i) Kljakic, O. (CA)
    Al-Onaizi, M. (CA)
    Janíčková, Helena (FGU-C) RID, ORCID, SAI
    Chen, K. S. (CA)
    Guzman, M. S. (CA)
    Prado, M. A. M. (CA)
    Prado, V. F. (CA)
    Zdroj.dok.European Journal of Neuroscience - ISSN 0953-816X
    Roč. 54, č. 6 (2021), s. 6075-6092
    Poč.str.18 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaacetylcholine ; autism ; forebrain ; schizophrenia ; social memory
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    Obor OECDNeurosciences (including psychophysiology
    Způsob publikováníOmezený přístup
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000684571500001
    EID SCOPUS85112382494
    DOI10.1111/ejn.15400
    AnotaceDisruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter—the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala, however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of social memory and social preference. Furthermore, we demonstrated that increasing global cholinergic tone does not increase social behaviours. Together, these data suggest that cholinergic transmission from the hippocampus and cortex are important for regulating social memory.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2022
    Elektronická adresahttps://doi.org/10.1111/ejn.15400
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.