Počet záznamů: 1
Equilibrium thermodynamics and the genesis of protein-protein complexes in cells
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SYSNO ASEP 0545775 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Equilibrium thermodynamics and the genesis of protein-protein complexes in cells Tvůrce(i) Jennings, R.C. (IT)
Belgio, Erica (MBU-M)
Zucchelli, G. (IT)Zdroj.dok. Rendiconti Lincei. Scienze Fisiche e Naturali. - : Springer - ISSN 2037-4631
Roč. 32, č. 3 (2021), s. 417-426Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. IT - Itálie Klíč. slova Thermodynamics in biology ; Biological complexity ; Subcellular complexes ; Multi-protein complexes ; Thermodynamics second law Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA19-11494S GA ČR - Grantová agentura ČR ED2.1.00/19.0392 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000663505000001 EID SCOPUS 85108338565 DOI 10.1007/s12210-021-01004-1 Anotace It is often thought that the structural complexity of living organisms places Life outside the laws of Physics. According to the Second Law of Thermodynamics, inanimate matter tends towards ever-increasing randomness. Most thermodynamic studies on the living system are course-grained in the sense that it is the whole organism which is considered and they lack microscopic details. In these studies, as the living system is an open system, non-linear thermodynamics have been used. This requires that a number of assumptions be made concerning the living system itself, which may not be correct in organisms living under natural environmental conditions. In the present study, we depart from this approach and use a fine-grained analysis of the genesis of subcellular protein complex structures. The analysis is performed in terms of classical equilibrium thermodynamics using the acquired knowledge of protein/protein interactions. In this way, it is demonstrated that the spontaneous creation of ordered subcellular structures occurs in accordance with the Second Law of Thermodynamics. We specifically consider the simple example of protein dimer and trimer formation from its monomer components, both in vitro and with chaperone assistance in vivo. The entropy decrease associated with protein complex assembly, on which the continuing debate is founded, is shown to be a relatively small component in the overall and positive entropy increase. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://link.springer.com/article/10.1007%2Fs12210-021-01004-1
Počet záznamů: 1