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In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers
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SYSNO ASEP 0545306 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers Tvůrce(i) Minisy, Islam M. (UMCH-V) RID, ORCID
Salahuddin, N. A. (EG)
Ayad, M. M. (EG)Zdroj.dok. Polymer Bulletin. - : Springer - ISSN 0170-0839
Roč. 78, č. 10 (2021), s. 5609-5622Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova drug delivery ; chitosan/polyaniline hybrid ; ketoprofen Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000575725000004 EID SCOPUS 85092110692 DOI 10.1007/s00289-020-03385-z Anotace Chitosan/polyaniline nanofibers (CH/PANI) were prepared by an in situ oxidative polymerization of aniline in the presence of CH solution. An attractive development of nanofibers network provides free volume space for the easy encapsulation of drugs in the three-dimensional network structure. The CH/PANI hybrid was characterized by using Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Ketoprofen (KP), a model drug that contains a carboxylic group and a hydrophobic moiety, was loaded into CH/PANI hybrid. The release of KP from the hybrid was recorded in aqueous buffer solutions of pH 2, 6.7 and 7.4 simulating the case of oral administration. The release rate was found to be changing with the pH of the medium. The kinetics of the drug delivery system have been systematically studied by different models, which are commonly used, such as zero order, first order, Hixson–Crowell, Higuchi and Korsmeyer–Peppas models. The mechanism of release of the drug was found to follow the anomalous non-Fickian diffusion. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://link.springer.com/article/10.1007%2Fs00289-020-03385-z
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