Počet záznamů: 1
Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation
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SYSNO ASEP 0545000 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation Tvůrce(i) Roubalová, Radka (MBU-M) RID, ORCID
Procházková, Petra (MBU-M) RID, ORCID
Dvořák, Jiří (MBU-M) RID, ORCID
Hill, M. (CZ)
Papežová, H. (CZ)
Kreisinger, J. (CZ)
Bulant, J. (CZ)
Lambertová, A. (CZ)
Holanová, P. (CZ)
Bilej, Martin (MBU-M) RID, ORCID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDČíslo článku 680870 Zdroj.dok. Frontiers in Nutrition. - : Frontiers Research Foundation - ISSN 2296-861X
Roč. 8, AUG 2 2021 (2021)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova realimentation ; anorexia-nervosa ; realimentation ; alpha-melanocyte stimulating hormone ; immune system ; autoantibody ; Enterobacteriaceae ; microbiota Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP NV17-28905A GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000685529300001 EID SCOPUS 85112756423 DOI https://doi.org/10.3389/fnut.2021.680870 Anotace Anorexia nervosa (AN) is a life-threatening psychiatric disorder with not well-described pathogenesis. Besides the genetic and sociological factors, autoimmunity is also considered to take part in AN pathogenesis. We evaluated general serological factors showing the physiological state of 59 patients with AN at hospital admission and their discharge. We detected the altered levels of some general biochemical and immunological parameters. We also detected decreased levels of appetite-regulating alpha-melanocyte stimulating hormone (alpha-MSH) in patients at hospital admission. Moreover, elevated anti-alpha-MSH IgM levels and decreased anti-alpha-MSH IgA levels were observed in patients with AN. Therefore, we analyzed the gut microbiota composition with special focus on alpha-MSH antigen-mimetic containing microbes from the Enterobacteriaceae family. We correlated gut bacterial composition with anti-alpha-MSH Ig levels and detected decreasing IgG levels with increasing alpha diversity. The upregulation of pro-inflammatory cytokines IL-6, IL-17, and TNF-alpha were detected in patients with AN both prior and after hospitalization. We also evaluated the treatment outcome and improvement was observed in the majority of patients with AN. We provide new data about various serum biochemical parameters and their changes during the patients' hospitalization, with emphasis on the immune system, and its possible participation in AN pathogenesis. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fnut.2021.680870/full
Počet záznamů: 1