Počet záznamů: 1
PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging
- 1.0543052 - ÚMCH 2022 RIV US eng J - Článek v odborném periodiku
Kostiv, Uliana - Natile, M. M. - Jirák, D. - Půlpánová, D. - Jiráková, K. - Vosmanská, M. - Horák, Daniel
PEG-neridronate-modified NaYF4:Gd3+,Yb3+,Tm3+/NaGdF4 core-shell upconverting nanoparticles for bimodal magnetic resonance/optical luminescence imaging.
ACS Omega. Roč. 6, č. 22 (2021), s. 14420-14429. ISSN 2470-1343. E-ISSN 2470-1343
Grant CEP: GA ČR(CZ) GA19-00676S
Grant ostatní: AV ČR(CZ) CNR-19-16
Program: Bilaterální spolupráce
Institucionální podpora: RVO:61389013
Klíčová slova: upconverting * nanoparticles * core-shell
Obor OECD: Polymer science
Impakt faktor: 4.132, rok: 2021
Způsob publikování: Open access
https://pubs.acs.org/doi/10.1021/acsomega.1c01313
Upconverting nanoparticles are attracting extensive interest as a multimodal imaging tool. In this work, we report on the synthesis and characterization of gadolinium-enriched upconverting nanoparticles for bimodal magnetic resonance and optical luminescence imaging. NaYF4:Gd3+,Yb3+,Tm3+ core upconverting nanoparticles were obtained by a thermal coprecipitation of lanthanide oleate precursors in the presence of oleic acid as a stabilizer. With the aim of improving the upconversion emission and increasing the amount of Gd3+ ions on the nanoparticle surface, a 2.5 nm NaGdF4 shell was grown by the epitaxial layer-by-layer strategy, resulting in the 26 nm core–shell nanoparticles. Both core and core–shell nanoparticles were coated with poly(ethylene glycol) (PEG)-neridronate (PEG-Ner) to have stable and well-dispersed upconverting nanoparticles in a biological medium. FTIR spectroscopy and thermogravimetric analysis indicated the presence of ∼20 wt % of PEG-Ner on the nanoparticle surface. The addition of inert NaGdF4 shell resulted in a total 26-fold enhancement of the emission under 980 nm excitation and also affected the T1 and T2 relaxation times. Both r1 and r2 relaxivities of PEG-Ner-modified nanoparticles were much higher compared to those of non-PEGylated particles, thus manifesting their potential as a diagnostic tool for magnetic resonance imaging. Together with the enhanced luminescence efficiency, upconverting nanoparticles might represent an efficient probe for bimodal in vitro and in vivo imaging of cells in regenerative medicine, drug delivery, and/or photodynamic therapy.
Trvalý link: http://hdl.handle.net/11104/0320855
Počet záznamů: 1