Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Williams, W. B.; Meyerhoff, R. R.; Edwards, R. J.; Li, H.; Manne, K.; Nicely, N. I.; Henderson, R.; Zhou, Y.; Janowska, K.; Mansouri, K.; Gobeil, S.; Evangelous, T.; Hora, B.; Berry, M.; Abuahmad, A. Y.; Sprenz, J.; Deyton, M.; Stalls, V.; Kopp, M.; Hsu, A. L.; Borgnia, M. J.; Stewart-Jones, G. B. E.; Lee, M. S.; Bronkema, N.; Moody, M. A.; Wiehe, K.; Bradley, T.; Alam, S. M.; Parks, R. J.; Foulger, A.; Oguin, T.; Sempowski, G. D.; Bonsignori, M.; LaBranche, C. C.; Montefiori, D. C.; Seaman, M.; Santra, S.; Perfect, J.; Francica, J. R.; Lynn, G. M.; Aussedat, B.; Walkowicz, W. E.; Laga, Richard; Kelsoe, G.; Saunders, K. O.; Fera, D.; Kwong, P. D.; Seder, R. A.; Bartesaghi, A.; Shaw, G. M.; Acharya, P.; Haynes, B. F.

doi:https://dx.doi.org/10.1016/j.cell.2021.04.042

Počet záznamů: 1

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

1.

SYSNO ASEP	0542811
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies
Tvůrce(i)	Williams, W. B. (US) Meyerhoff, R. R. (US) Edwards, R. J. (US) Li, H. (US) Manne, K. (US) Nicely, N. I. (US) Henderson, R. (US) Zhou, Y. (US) Janowska, K. (US) Mansouri, K. (US) Gobeil, S. (US) Evangelous, T. (US) Hora, B. (US) Berry, M. (US) Abuahmad, A. Y. (US) Sprenz, J. (US) Deyton, M. (US) Stalls, V. (US) Kopp, M. (US) Hsu, A. L. (US) Borgnia, M. J. (US) Stewart-Jones, G. B. E. (US) Lee, M. S. (US) Bronkema, N. (US) Moody, M. A. (US) Wiehe, K. (US) Bradley, T. (US) Alam, S. M. (US) Parks, R. J. (US) Foulger, A. (US) Oguin, T. (US) Sempowski, G. D. (US) Bonsignori, M. (US) LaBranche, C. C. (US) Montefiori, D. C. (US) Seaman, M. (US) Santra, S. (US) Perfect, J. (US) Francica, J. R. (US) Lynn, G. M. (US) Aussedat, B. (US) Walkowicz, W. E. (US) Laga, Richard (UMCH-V)_{RID, ORCID} Kelsoe, G. (US) Saunders, K. O. (US) Fera, D. (US) Kwong, P. D. (US) Seder, R. A. (US) Bartesaghi, A. (US) Shaw, G. M. (US) Acharya, P. (US) Haynes, B. F. (US)
Zdroj.dok.	Cell. - : Cell Press - ISSN 0092-8674 Roč. 184, č. 11 (2021), s. 2955-2972.e25
Poč.str.	17 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	natural Abs ; glycan-dependent Ab binding ; HIV-1 Env glycans
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
Způsob publikování	Open access
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000656965600013
EID SCOPUS	85106501678
DOI	10.1016/j.cell.2021.04.042
Anotace	Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (VH) domain-swapped architecture that results in fragment antigen-binding (Fab) dimerization. Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without VH-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques. FDG Abs also recognized cell-surface glycans on diverse pathogens, including yeast and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike. FDG precursors were expanded by glycan-bearing immunogens in macaques and were abundant in HIV-1-naive humans. Moreover, FDG precursors were predominately mutated IgM+IgD+CD27+, thus suggesting that they originated from a pool of antigen-experienced IgM+ or marginal zone B cells.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2022
Elektronická adresa	https://www.sciencedirect.com/science/article/pii/S0092867421005778?via%3Dihub

Počet záznamů: 1