Počet záznamů: 1
Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters
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SYSNO ASEP 0542409 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters Tvůrce(i) Vojtěchová, Iveta (FGU-C) ORCID, RID
Malenínská, Kristýna (FGU-C) ORCID, RID
Kútna, V. (CZ)
Klovrza, O. (CZ)
Tučková, K. (CZ)
Petrásek, Tomáš (FGU-C) RID, ORCID, SAI
Stuchlík, Aleš (FGU-C) RID, ORCIDČíslo článku 3274 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 6 (2021)Poč.str. 31 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova lipopolysaccharide ; maternal immune activation ; prenatal infection ; chronic bacterial infection ; parvalbumin-positive interneurons ; macrocephaly ; schizophrenia ; autism ; sex differences ; development Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA19-03016S GA ČR - Grantová agentura ČR NV17-30833A GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000645699300001 EID SCOPUS 85102846319 DOI 10.3390/ijms22063274 Anotace Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior of adolescent and adult offspring, as a rat model of these neurodevelopmental disorders. We injected bacterial lipopolysaccharide (LPS, 1 mg/kg) to pregnant Wistar dams from gestational day 7, every other day, up to delivery. Behavior of the offspring was examined in a comprehensive battery of tasks at postnatal days P45 and P90. Several brain parameters were analyzed at P28. The results showed that prenatal immune activation caused social and communication impairments in the adult offspring of both sexes, males were affected already in adolescence. MIA also caused prepulse inhibition deficit in females and increased the startle reaction in males. Anxiety and hypolocomotion were apparent in LPS-affected males and females. In the 28-day-old LPS offspring, we found enlargement of the brain and decreased numbers of parvalbumin-positive interneurons in the frontal cortex in both sexes. To conclude, our data indicate that sex of the offspring plays a crucial role in the development of the MIA-induced behavioral alterations, whereas changes in the brain apparent in young animals are sex-independent. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/1422-0067/22/6/3274
Počet záznamů: 1