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Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors
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SYSNO ASEP 0538527 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors Tvůrce(i) Artero-Castro, A. (ES)
Rodriguez-Jiménez, F.J. (ES)
Jendelová, Pavla (UEM-P) RID, ORCID
VanderWall, K.B. (US)
Jason, S.M. (US)
Erceg, Slaven (UEM-P) RID, ORCIDČíslo článku 101817 Zdroj.dok. Progress in Neurobiology. - : Elsevier - ISSN 0301-0082
Roč. 193, oct (2020)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova environment ; biomonitoring ; biomarkers Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA18-04393S GA ČR - Grantová agentura ČR EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000541933800002 EID SCOPUS 85086565479 DOI 10.1016/j.pneurobio.2020.101817 Anotace Glaucoma, one of the most common causes of blindness in developing countries today, involves a progressive loss of neural cells in the optic nerve that leads to progressive, irreversible vision loss. Increased intraocular pressure (IOP) presents as a major risk factor for glaucoma, although there exist cases of glaucoma patients with normal IOP that exhibit damage to retinal ganglion cells (RGCs) and the optic nerve. However, treatment approaches have maintained their focus on modifying IOP due to a lack of other modifiable risks factors. Traditional concepts in glaucoma involve the neuronal environment and external effects as a source of causative factors, however, studies have yet to investigate whether the molecular profile of RGCs in glaucoma patients makes them more vulnerable and/or susceptible to external damage. Our hypothesis states that molecular changes at the whole cell, gene expression, and electrophysiological level of the neurons can contribute to their degeneration. Herein, we briefly describe different types of glaucoma and any similarities to different molecular and cellular features of neurodegeneration. To test our hypothesis, we describe human induced pluripotent stem cells (hiPSCs) as a reliable cellular tool to model neurodegenerative aspects of glaucoma to reveal the multiple pathological molecular mechanisms underlying disease development. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2021 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0301008220300721?via%3Dihub
Počet záznamů: 1