0537775 - FZÚ 2021 RIV CH eng J - Článek v odborném periodiku
Khandavilli, U.B.R. - Keshavarz, L. - Skořepová, Eliška - Steendam, R.R.E. - Frawley, P.J.
Organic salts of pharmaceutical impurity p-Aminophenol.
Molecules. Roč. 25, č. 8 (2020), s. 1-10, č. článku 1910. E-ISSN 1420-3049
Grant CEP: GA TA ČR TJ02000256; GA ČR GA17-23196S
Institucionální podpora: RVO:68378271
Klíčová slova: paracetamol * 4-aminophenol or p-aminophenol * salt * impurity removal * particle size
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 4.412, rok: 2020
Způsob publikování: Open access

The presence of impurities can drastically affect the efficacy and safety of pharmaceutical entities. p-Aminophenol (PAP) is one of the main impurities of paracetamol (PA) that can potentially show toxic effects such as maternal toxicity and nephrotoxicity. The removal of PAP from PA is challenging and difficult to achieve through regular crystallization approaches. In this regard, we report four new salts of PAP with salicylic acid (SA), oxalic acid (OX), l-tartaric acid (TA), and (1S)-(+)-10-camphorsulfonic acid (CSA). All the PAP salts were analyzed using single-crystal X-ray di raction, powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. In our study, we found that the addition of small quantities of the aforementioned acids helps to remove PAP from PA during the filtration and washings.
Trvalý link: http://hdl.handle.net/11104/0315615