Počet záznamů: 1
Translational Research in Serious Human Diseases
- 1.0536484 - ÚŽFG 2021 RIV CZ eng M - Část monografie knihy
Klíma, Jiří
Huntington´s disease modeling in animals.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 20-29. ISBN 978-80-200-3158-7
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: Huntington´s disease * animal model * mutant huntingtin
Obor OECD: Cell biology
Animal models are valuable tools in the determination of expression and physiologic function of studied genes. Huntington's disease as monogenic autosomal disorder is still enigmatic in mechanism by which mutant gene expression affects molecular, physiological, and neurological functions in patients. Recently many animal genetic models were established in an effort to determine and understand changes in tissues and organs leading to disease onset, its progression and manifestation.
Trvalý link: http://hdl.handle.net/11104/0314256
Počet záznamů: 1