Počet záznamů: 1
Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.
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SYSNO ASEP 0535687 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years. Tvůrce(i) Pelclová, D. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Komarc, M. (CZ)
Schwarz, Jaroslav (UCHP-M) RID, ORCID, SAI
Ondráček, Jakub (UCHP-M) RID, ORCID, SAI
Ondráčková, Lucie (UCHP-M) RID, ORCID, SAI
Koštejn, Martin (UCHP-M) RID, SAI, ORCID
Vlčková, Š. (CZ)
Fenclová, Z. (CZ)
Dvořáčková, Š. (CZ)
Lischová, L. (CZ)
Klusáčková, P. (CZ)
Klesnikova, V. (CZ)
Rössnerová, Andrea (UEM-P) RID
Navrátil, Tomáš (UFCH-W) RID, ORCIDČíslo článku 2440 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 10, č. 12 (2020)Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova nanoparticles ; oxidative stress ; biomarkers ; workers ; controls Vědní obor RIV DN - Vliv životního prostředí na zdraví Obor OECD Public and environmental health Vědní obor RIV – spolupráce Ústav experimentální medicíny - Vliv životního prostředí na zdraví
Ústav fyzikální chemie J.Heyrovského - Fyzikální chemie a teoretická chemieCEP GA18-02079S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UCHP-M - RVO:67985858 ; UEM-P - RVO:68378041 ; UFCH-W - RVO:61388955 UT WOS 000602622000001 EID SCOPUS 85097542423 DOI 10.3390/nano10122440 Anotace Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018, all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2079-4991/10/12/2440/pdf
Počet záznamů: 1