Počet záznamů: 1
Intra-species differences in population size shape life history and genome evolution
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SYSNO ASEP 0532191 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Intra-species differences in population size shape life history and genome evolution Tvůrce(i) Willemsen, D. (DE)
Cui, R. (DE)
Reichard, Martin (UBO-W) RID, ORCID, SAI
Valenzano, D. R. (DE)Celkový počet autorů 4 Číslo článku e55794 Zdroj.dok. eLife. - : eLife - ISSN 2050-084X
Roč. 9, September (2020)Poč.str. 26 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova aging ; evolution ; evolutionary biology ; genetics ; genomics ; lifespan ; nothobranchius furzeri ; turquoise killifish Vědní obor RIV EG - Zoologie Obor OECD Zoology CEP GA19-01781S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 UT WOS 000567779400001 EID SCOPUS 85090104439 DOI https://doi.org/10.7554/eLife.55794 Anotace The evolutionary forces shaping life history divergence within species are largely unknown. Turquoise killifish display differences in lifespan among wild populations, representing an ideal natural experiment in evolution and diversification of life history. By combining genome sequencing and population genetics, we investigate the evolutionary forces shaping lifespan among wild turquoise killifish populations. We generate an improved reference genome assembly and identify genes under positive and purifying selection, as well as those evolving neutrally. Short-lived populations from the outer margin of the species range have small population size and accumulate deleterious mutations in genes significantly enriched in the WNT signaling pathway, neurodegeneration, cancer and the mTOR pathway. We propose that limited population size due to habitat fragmentation and repeated population bottlenecks, by increasing the genome-wide mutation load, exacerbates the effects of mutation accumulation and cumulatively contribute to the short adult lifespan. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2021 Elektronická adresa https://elifesciences.org/articles/55794
Počet záznamů: 1