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Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice
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SYSNO ASEP 0532017 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice Tvůrce(i) Kroupová, Petra (FGU-C) ORCID
van Schothorst, E. M. (NL)
Keijer, J. (NL)
Bunschoten, A. (NL)
Vodička, Martin (FGU-C) RID, ORCID, SAI
Irodenko, Ilaria (FGU-C) RID
Oseeva, Marina (FGU-C) ORCID, RID
Žáček, P. (CZ)
Kopecký, Jan (FGU-C) RID, ORCID
Rossmeisl, Martin (FGU-C) RID, ORCID
Horáková, Olga (FGU-C) RID, ORCIDČíslo článku 2037 Zdroj.dok. Nutrients. - : MDPI - ISSN 2072-6643
Roč. 12, č. 7 (2020)Poč.str. 20 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova krill oil ; Omega-3 phospholipids ; high-fat diet ; Omega-3 index ; small intestine Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa Obor OECD Endocrinology and metabolism (including diabetes, hormones) CEP GA16-08124S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000556892600001 EID SCOPUS 85087630620 DOI https://doi.org/10.3390/nu12072037 Anotace Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil, omega 3PL-H) and triacylglycerols (omega 3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of omega 3TG or omega 3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the omega 3PL-H and omega 3TG groups, respectively. Compared to HFD mice, omega 3PL-H but not omega 3TG animals had lower body weight gain (-40%), mesenteric adipose tissue (-43%), and hepatic lipid content (-64%). The highest number and expression level of regulated intestinal genes was observed in omega 3PL-H mice. The expression of FA omega-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA beta-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in omega 3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2072-6643/12/7/2037
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