Počet záznamů: 1
Organization of gangliosides into membrane nanodomains
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SYSNO ASEP 0531042 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Organization of gangliosides into membrane nanodomains Tvůrce(i) Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Ricardo, Joana Catarina (UFCH-W) ORCID, SAI, RID
Amaro, Mariana (UFCH-W) RID, ORCID
Šachl, Radek (UFCH-W) RID, ORCIDZdroj.dok. FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 594, č. 22 (2020), s. 3668-3697Poč.str. 30 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova afm ; diffusion ; diffusion laws ; gangliosides ; gm 1 ; lipid bilayers ; mc-fret ; membrane model systems ; nanodomains ; phase separation Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA18-04871S GA ČR - Grantová agentura ČR GC20-01401J GA ČR - Grantová agentura ČR EF16_027/0008355 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000546730400001 EID SCOPUS 85087739001 DOI 10.1002/1873-3468.13871 Anotace Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain that contains one or more sialic acids. This unique structure endows gangliosides with a strong tendency to self-aggregate in solution, as well as in cellular membranes, where they can form nanoscopic assemblies called ganglioside nanodomains. As gangliosides are important biological molecules involved in a number of physiological processes, characterization of their lateral organization in membranes is essential. This review aims at providing comprehensive information about the nanoscale organization of gangliosides in various synthetic models. To this end, the impact of the hydrophobic backbone and the headgroup on the segregation of gangliosides into nanodomains are discussed in detail, as well as the way in which the properties of nanodomains are affected by ligand binding. Small size makes the characterization of ganglioside nanodomains challenging, and we thus highlight the biophysical methods that have advanced this research, such as Monte Carlo Förster resonance energy transfer, atomic force microscopy and approaches based on molecular diffusion. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0309799
Počet záznamů: 1