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A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria
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SYSNO ASEP 0525046 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria Tvůrce(i) Sur, V. P. (CZ)
Mazumdar, A. (CZ)
Kopel, P. (CZ)
Mukherjee, S. (IN)
Vítek, Petr (UEK-B) RID, SAI
Michalkova, H. (CZ)
Vaculovičová, M. (CZ)
Moulick, A. (CZ)Celkový počet autorů 8 Číslo článku 2656 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 7 (2020)Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova staphylococcus-aureus ; antimicrobial agent ; quantum dots ; schiff-bases ; complexes ; antibacterial ; nanoparticles ; methicillin ; model ; metalloproteinases ; coordination compound ; antimicrobial compound ; ruthenium ; benzimidazole ; sem ; eds Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Biophysics Výzkumná infrastruktura CzeCOS III - 90123 - Ústav výzkumu globální změny AV ČR, v. v. i. Způsob publikování Open access Institucionální podpora UEK-B - RVO:86652079 UT WOS 000535574200398 EID SCOPUS 85083406638 DOI 10.3390/ijms21072656 Anotace The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4. Pracoviště Ústav výzkumu globální změny Kontakt Nikola Šviková, svikova.n@czechglobe.cz, Tel.: 511 192 268 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/1422-0067/21/7/2656
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