Simple syntheses of new Pegylated trehalose derivatives as a chemical tool for potential evaluation of cryoprotectant effects on cell membrane

0524783 - FZÚ 2021 RIV CH eng J - Článek v odborném periodiku
Pomeisl, Karel - Richter, J. - Golan, Martin - Kratochvílová, Irena
Simple syntheses of new Pegylated trehalose derivatives as a chemical tool for potential evaluation of cryoprotectant effects on cell membrane.
Molecules. Roč. 25, č. 3 (2020), s. 1-14, č. článku 497. E-ISSN 1420-3049
Grant CEP: GA MŠMT EF16_013/0001406; GA MŠMT(CZ) LO1409
Grant ostatní: OP VVV - SAFMAT(XE) CZ.02.1.01/0.0/0.0/16_013/0001406
Institucionální podpora: RVO:68378271
Klíčová slova: click-chemistry * pegylation * cryoprotection
Obor OECD: Biophysics
Impakt faktor: 4.412, rok: 2020
Způsob publikování: Open access

In our work, we developed the synthesis of new polyfunctional pegylated trehalose derivatives and evaluated their cryoprotective effect using flow cytometry. We showed that new compounds (modified trehaloses) bound to appropriate extracellular polymeric cryoprotectants could be helpful as a chemical tool for the evaluation of their potential toxic cell membrane influences. Our aim was to form a chemical tool for the evaluation of cryoprotectant cell membrane influences, which are still not easily predicted during the freezing/thawing process. We combined two basic cryoprotectants: polyethyleneglycols (PEGs) and trehalose in the new chemical compounds—pegylated trehalose hybrids.

Trvalý link: http://hdl.handle.net/11104/0309075