Počet záznamů: 1
Advances in Disease Models
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SYSNO ASEP 0523210 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models Tvůrce(i) Zimmann, F. (CZ)
Staněk, David (UMG-J) RIDZdroj.dok. Advances in Disease Models. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-06-4 Rozsah stran s. 1-310 Poč.str. 10 s. Poč.výt. 50 Poč.str.knihy 310 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova retinitis pigmentosa ; human stem cell derived disease model ; retinal organoids Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP LO1419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 Anotace Given complexity and health impact of retinitis pigmentosa a better understanding of its pathogenesis is of major importance. Often used research models, such as mouse models, have been shown to insufficiently recapitulate the retinitis pigmentosa phenotype as it is observed in human patients. With the invention of induced pluripotent stem cells and the advances in retinal differentiation in the last decade new possibilities for retinal disease modeling have emerged. Two-dimensional and even three-dimensional in vitro models, known as retinal organoids, have been successfully derived from human stem cells. In this manuscript we describe and discuss the development of these stem cell derived retina models and their applications in retinitis pigmentosa research. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2020
Počet záznamů: 1