Počet záznamů: 1
Non-thermal plasma, as a new physicochemical source, to induce redox imbalance and subsequent cell death in liver cancer cell lines
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SYSNO ASEP 0521395 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název Non-thermal plasma, as a new physicochemical source, to induce redox imbalance and subsequent cell death in liver cancer cell lines Tvůrce(i) Smolková, Barbora (FZU-D) ORCID
Lunova, Mariia (FZU-D) ORCID
Lynnyková, Anna (FZU-D) RID
Uzhytchak, Mariia (FZU-D) ORCID
Churpita, Olexandr (FZU-D) RID, ORCID
Jirsa, M. (CZ)
Kubinová, Šárka (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCIDCelkový počet autorů 9 Zdroj.dok. Cellular Physiology and Biochemistry. - : Cellular Physiology and Biochemistry - ISSN 1015-8987
Roč. 52, č. 1 (2019), s. 119-140Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova oxidative stress ; reactive oxygen species ; apoptosis ; non-thermal plasma ; stress resistance Vědní obor RIV BO - Biofyzika Obor OECD Biophysics CEP FV10081 GA MPO - Ministerstvo průmyslu a obchodu EF16_019/0000760 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Fellowship J. E. Purkyně GA AV ČR - Akademie věd Způsob publikování Open access Institucionální podpora FZU-D - RVO:68378271 EID SCOPUS 85061973909 DOI 10.33594/000000009 Anotace In recent years, the emerged field of non-thermal plasma (NTP) has shown considerable promise in various biomedical applications, including cancer therapy. However, understanding the molecular mechanisms procuring cellular responses remains incomplete. Thus, the aim of this study was a rigorous biochemical analysis of interactions between NTP and liver cancer cells. We assessed the influence of NTP on three human liver cancer cell lines (Huh7, Alexander and HepG2). NTP treatment resulted in higher anti-proliferative effect against Alexander and Huh7 relative to HepG2. Our data clearly showed that the NTP-mediated alternation of mitochondrial membrane potential and dynamics led to ROS-mediated apoptosis in Huh7 and Alexander cells. Interestingly, plasma treatment resulted in p53 down-regulation in Huh7 cells. High levels of Bcl-2 protein expression in HepG2 resulted in their resistance in response to oxidative stress- mediated by plasma. Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2020 Elektronická adresa http://hdl.handle.net/11104/0306026
Počet záznamů: 1