Počet záznamů: 1
Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation
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SYSNO ASEP 0519332 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation Tvůrce(i) Procházková, Petra (MBU-M) RID, ORCID
Roubalová, Radka (MBU-M) RID, ORCID
Dvořák, Jiří (MBU-M) RID, ORCID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCID
Čermáková, Martina (MBU-M) ORCID
Tomášová, Petra (MBU-M)
Šedivá, Blanka (MBU-M) ORCID
Kuzma, Marek (MBU-M) ORCID, RID
Bulant, J. (CZ)
Bilej, Martin (MBU-M) RID, ORCID
Hrabák, P. (CZ)
Meisnerová, E. (CZ)
Lambertová, A. (CZ)
Papežová, H. (CZ)Číslo článku 338 Zdroj.dok. Microorganisms. - : MDPI
Roč. 7, č. 9 (2019)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova microbiome ; microbial metabolites ; fecal microbiota transplantation (FMT) Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP NV17-28905A GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000489131300065 EID SCOPUS 85074338940 DOI 10.3390/microorganisms7090338 Anotace The change in the gut microbiome and microbial metabolites in a patient suffering from severe and enduring anorexia nervosa (AN) and diagnosed with small intestinal bacterial overgrowth syndrome (SIBO) was investigated. Microbial gut dysbiosis is associated with both AN and SIBO, and therefore gut microbiome changes by serial fecal microbiota transplantation (FMT) is a possible therapeutic modality. This study assessed the effects of FMT on gut barrier function, microbiota composition, and the levels of bacterial metabolic products. The patient treatment with FMT led to the improvement of gut barrier function, which was altered prior to FMT. Very low bacterial alpha diversity, a lack of beneficial bacteria, together with a great abundance of fungal species were observed in the patient stool sample before FMT. After FMT, both bacterial species richness and gut microbiome evenness increased in the patient, while the fungal alpha diversity decreased. The total short-chain fatty acids (SCFAs) levels (molecules presenting an important source of energy for epithelial gut cells) gradually increased after FMT. Contrarily, one of the most abundant intestinal neurotransmitters, serotonin, tended to decrease throughout the observation period. Overall, gut microbial dysbiosis improvement after FMT was considered. However, there were no signs of patient clinical improvement. The need for an in-depth analysis of the donor's stool and correct selection pre-FMT is evident. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://www.mdpi.com/2076-2607/7/9/338
Počet záznamů: 1