Počet záznamů: 1
DNA methylation and chromatin modifiers in colorectal cancer.
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SYSNO ASEP 0518158 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název DNA methylation and chromatin modifiers in colorectal cancer. Tvůrce(i) Vymetálková, Veronika (UEM-P) RID
Vodička, Pavel (UEM-P) RID
Vodenková, Soňa (UEM-P) ORCID, RID
Alonso, A. (ES)
Schneider-Stock, R. (DE)Zdroj.dok. Molecular Aspects of Medicine. - : Elsevier - ISSN 0098-2997
Roč. 69, SI (2019), s. 73-92Poč.str. 20 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova colorectal cancer ; colorectal cancer ; DNA methylation Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Human genetics CEP NV18-03-00199 GA MZd - Ministerstvo zdravotnictví NV17-30920A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000486385900008 EID SCOPUS 85064905503 DOI 10.1016/j.mam.2019.04.002 Anotace Colorectal carcinogenesis is a multistep process involving the accumulation of genetic alterations over time that ultimately leads to disease progression and metastasis. Binding of transcription factors to gene promoter regions alone cannot explain the complex regulation pattern of gene expression during this process. It is the chromatin structure that allows for a high grade of regulatory flexibility for gene expression. Posttranslational modifications on histone proteins such as acetylation, methylation, or phosphorylation determine the accessibility of transcription factors to DNA. DNA methylation, a chemical modification of DNA that modulates chromatin structure and gene transcription acts in concert with these chromatin conformation alterations. Another epigenetic mechanism regulating gene expression is represented by small non-coding RNAs. Only very recently epigenetic alterations have been included in molecular subtype classification of colorectal cancer (CRC). In this chapter, we will provide examples of the different epigenetic players, focus on their role for epithelial-mesenchymal transition and metastatic processes and discuss their prognostic value in CRC. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0098299719300081?via%3Dihub
Počet záznamů: 1