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The effect of iodide and temperature on enhancing antibacterial properties of nanoparticles with an encapsulated photosensitizer
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SYSNO ASEP 0510021 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The effect of iodide and temperature on enhancing antibacterial properties of nanoparticles with an encapsulated photosensitizer Tvůrce(i) Kubát, Pavel (UFCH-W) RID, ORCID, SAI
Henke, P. (CZ)
Mosinger, Jiří (UACH-T) RID, ORCID, SAIZdroj.dok. Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765
Roč. 176, APR 2019 (2019), s. 334-340Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova antimicrobial photodynamic inactivation ; nanofiber materials ; photophysical properties ; escherichia-coli ; oxygen diffusion ; aggregation ; polystyrene ; surfaces ; Nanoparticles ; Potassium iodide Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry Vědní obor RIV – spolupráce Ústav anorganické chemie - Anorganická chemie CEP GA16-15020S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UFCH-W - RVO:61388955 ; UACH-T - RVO:61388980 UT WOS 000465051800038 EID SCOPUS 85059834822 DOI 10.1016/j.colsurfb.2019.01.021 Anotace Aqueous dispersions of sulfonated polystyrene nanoparticles (average diameter: 30 +/- 14 nm) with encapsulated 5,10,15,20-tetraphenylporphyrin (TPP) are promising candidates for antibacterial treatments due to the photogeneration of cytotoxic singlet oxygen species O-2((1)Delta(g)) under physiological conditions using visible light. The antibacterial effect on gram-negative Escherichia coli was significantly enhanced after the addition of nontoxic potassium iodide (0.001-0.01 M) because photogenerated O-2((1)Delta(g)) oxidized iodide to I-2/I-3(-), which is another antibacterial species. The improved antibacterial properties were predicted using luminescence measurements of O-2((1)Delta(g)), transient absorption of TPP triplets and singlet oxygen-sensitized delayed fluorescence (SODF). In contrast to a solution of free photosensitizers, the aqueous dispersion of photoactive nanoparticles did not exhibit any quenching of the excited states after the addition of iodide or any tendency toward aggregation and/or I-3(-)-induced photo-aggregation. We also observed a decrease in the lifetime of O-2((1)Delta(g)) and a significant increase in SODF intensity at higher temperatures, due to the increased oxygen diffusion coefficient in nanoparticles and aqueous surroundings. This effect corresponds with the significantly stronger antibacterial effect of nano particles at physiological temperature (37 degrees C) in comparison with that at room temperature (25 degrees C). Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2020 Elektronická adresa http://hdl.handle.net/11104/0300594
Počet záznamů: 1