0510001 - ÚBO 2020 RIV GB eng J - Článek v odborném periodiku
Chuma, I. S. - Roos, C. - Atickem, A. - Bohm, T. - Collins, D. A. - Grillová, L. - Hallmaier-Wacker, L. K. - Kazwala, R. R. - Keyyu, J. D. - Lüert, S. - Maloueki, U. - Oppelt, J. - Petrželková, Klára Judita - Piel, A. - Stewart, F. A. - Šmajs, D. - Knauf, S.
Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates.
Scientific Reports. Roč. 9, č. 1 (2019), č. článku 14243. ISSN 2045-2322. E-ISSN 2045-2322
Institucionální podpora: RVO:68081766
Klíčová slova: ribosomal-rna gene * macrolide resistance * infection * mutation * tree
Obor OECD: Veterinary science
Impakt faktor: 3.998, rok: 2019
Způsob publikování: Open access
http://dx.doi.org/10.1038/s41598-019-50779-9

In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
Trvalý link: http://hdl.handle.net/11104/0300574