Počet záznamů: 1
Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
- 1.
SYSNO ASEP 0508206 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy Tvůrce(i) Tomasetti, M. (IT)
Lee, W. (KR)
Santarelli, L. (IT)
Neužil, Jiří (BTO-N) RIDCelkový počet autorů 4 Číslo článku e285 Zdroj.dok. Experimental and Molecular Medicine - ISSN 1226-3613
Roč. 49, JAN 2017 (2017)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova tumor endothelial-cells ; mesenchymal stem-cells ; extracellular vesicles ; angiogenesis Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000393674100005 DOI 10.1038/emm.2016.153 Anotace Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell-cell communication by transferring nucleic acids and proteins to target cells and tissues. Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2020 Elektronická adresa https://www.nature.com/articles/emm2016153
Počet záznamů: 1