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Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states?
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SYSNO ASEP 0497265 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states? Tvůrce(i) Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Šupová, Monika (USMH-B) RID, ORCID, SAI
Bartoš, M. (CZ)
Sedláček, R. (CZ)
Piola, M. (IT)
Soncini, M. (IT)
Fiore, G.B. (IT)
Sauerová, P. (CZ)
Hubálek Kalbáčová, M. (CZ)Číslo článku 20 Zdroj.dok. Journal of Materials Science-Materials in Medicine. - : Springer - ISSN 0957-4530
Roč. 29, č. 2 (2018)Poč.str. 14 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova scaffolds ; collagen ; calcium compounds ; compression testing ; hydration ; infrared spectroscopy ; mechanical behaviour Vědní obor RIV FI - Traumatologie, ortopedie Obor OECD Medical engineering CEP NV15-25813A GA MZd - Ministerstvo zdravotnictví Institucionální podpora USMH-B - RVO:67985891 UT WOS 000426609600002 EID SCOPUS 85041447692 DOI 10.1007/s10856-017-6024-2 Anotace Collagen composite scaffolds have been used for a number of studies in tissue engineering. The hydration of such highly porous and hydrophilic structures may influence mechanical behaviour and porosity due to swelling. The differences in physical properties following hydration would represent a significant limiting factor for the seeding, growth and differentiation of cells in vitro and the overall applicability of such hydrophilic materials in vivo. Scaffolds based on collagen matrix, poly(DL-lactide) nanofibers, calcium phosphate particles and sodium hyaluronate with 8 different material compositions were characterised in the dry and hydrated states using X-ray microcomputed tomography, compression tests, hydraulic permeability measurement, degradation tests and infrared spectrometry. Hydration, simulating the conditions of cell seeding and cultivation up to 48 h and 576 h, was found to exert a minor effect on the morphological parameters and permeability. Conversely, hydration had a major statistically significant effect on the mechanical behaviour of all the tested scaffolds. The elastic modulus and compressive strength of all the scaffolds decreased by similar to 95%. The quantitative results provided confirm the importance of analysing scaffolds in the hydrated rather than the dry state since the former more precisely simulates the real environment for which such materials are designed. Pracoviště Ústav struktury a mechaniky hornin Kontakt Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Rok sběru 2019
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