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Alginate matrices for protein delivery - a short review
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SYSNO ASEP 0496666 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alginate matrices for protein delivery - a short review Tvůrce(i) Wawrzyńska, Edyta (UMCH-V) RID, ORCID
Kubies, Dana (UMCH-V) RID, ORCIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 67, Suppl. 2 (2018), S319-S334Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova protein ; growth factors ; alginate Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemical research methods CEP LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000450606900006 EID SCOPUS 85055856152 Anotace Growth factors are powerful molecules that regulate cellular growth, proliferation, healing, and cellular differentiation. A delivery matrix that incorporates growth factors with high loading efficiencies, controls their release, and maintains bioactivity would be a powerful tool for regenerative medicine. Alginate has several unique properties that make it an excellent platform for the delivery of proteins. Mild gelling conditions can minimize the risk of protein denaturation. Moreover, alginate can serve as protection from degradation until protein release. Various modifications have been proposed to tune alginate binding and release proteins, simultaneously adjusting alginate degradability, mechanical stiffness, swelling, gelation properties and cell affinity. The primary objective of this article is to review the literature related to recent advances in the application of alginate matrices in protein delivery in regenerative medicine. A special emphasis is put on the relevance of delivery of growth factors and chemokine. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019 Elektronická adresa http://www.biomed.cas.cz/physiolres/pdf/67/67_S319.pdf
Počet záznamů: 1