Počet záznamů: 1
Newborn foal with atypical myopathy
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SYSNO ASEP 0495766 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Newborn foal with atypical myopathy Tvůrce(i) Karlíková, H. (CZ)
Široká, Jitka (UEB-Q) ORCID
Mech, M. (CZ)
Friedecký, D. (CZ)
Janečková, H. (CZ)
Mádrová, L. (CZ)
Hrdinová, J. (CZ)
Drábková, Z. (CZ)
Dobešová, J. (CZ)
Adam, T. (CZ)
Jahn, P. (CZ)Celkový počet autorů 11 Zdroj.dok. Journal of Veterinary Internal Medicine. - : Wiley - ISSN 0891-6640
Roč. 32, č. 5 (2018), s. 1768-1772Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova acyl-coa dehydrogenase ; acer-pseudoplatanus ; hypoglycin ; horses ; acid ; inactivation ; intoxication ; deficiency ; metabolism ; placenta ; acylcarnitines ; hypoglycin A ; metabolomics ; methylenecyclopropyl acetyl carnitine ; multiple acyl-coenzyme A dehydrogenase deficiency Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Other clinical medicine subjects CEP LO1304 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000447414300034 EID SCOPUS 85053623609 DOI 10.1111/jvim.15236 Anotace The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal's dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal's blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare's placenta with consequent transfer to fetus or (b) these compounds were secreted into mare's milk. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2019
Počet záznamů: 1