N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs

Zimmermann, S. C., Tichý, T., Vávra, J., Dash, R. P., Slusher, C. E., Gadiano, A. J., Wu, Y., Jančařík, A., Tenora, L., Monincová, L., Prchalová, E., Riggins, G. J., Majer, P., Slusher, B. S., Rais, R. N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs. Journal of Medicinal Chemistry. 2018, 61(9), 3918-3929. ISSN 0022-2623. E-ISSN 1520-4804. Dostupné z: doi: 10.1021/acs.jmedchem.7b01792