Počet záznamů: 1
A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent
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SYSNO ASEP 0489993 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent Tvůrce(i) Phukan, B. (IN)
Mukherjee, C. (IN)
Goswami, U. (IN)
Sarmah, Amrit (UOCHB-X) ORCID
Mukherjee, S. (IN)
Sahoo, S. K. (IN)
Moi, S. C. (IN)Zdroj.dok. Inorganic Chemistry. - : American Chemical Society - ISSN 0020-1669
Roč. 57, č. 5 (2018), s. 2631-2638Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova nephrogenic systemic fibrosis ; Mn2+ complexes ; gadolinium complex Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000427094000035 EID SCOPUS 85042920839 DOI 10.1021/acs.inorgchem.7b03039 Anotace Disclosed here are a piperazine, a pyridine, and two carboxylate groups containing pentadentate ligand H(2)pmpa and its corresponding water-soluble Mn(II) complex (1). DFT-based structural optimization implied that the complex had pentagonal bipyramidal geometry where the axial positions were occupied by two water molecules, and the equatorial plane was constituted by the ligand ON3O donor set. Thus, a bis(aquated) disc-like Mn(II) complex has been synthesized. The complex showed higher stability compared with Mn(II)-EDTA complex [logK(MnL) = 14.29(3)] and showed a very high r(1) relaxivity value of 5.88 mM(-1) s(-1) at 1.41 T, 25 degrees C, and pH = 7.4. The relaxivity value remained almost unaffected by the pH of the medium in the range of 6-10. Although the presence of 200 equiv of fluoride and bicarbonate anions did not affect the relaxivity value appreciably, an increase in the value was noticed in the presence of phosphate anion due to slow tumbling of the complex. Cell viability measurements, as well as phantom MR images using clinical MRI imager, consolidated the possible candidature of complex 1 as a positive contrast agent. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2019
Počet záznamů: 1