Počet záznamů: 1
Improving hemocompatibility of membranes for extracorporeal membrane oxygenators by grafting nonthrombogenic polymer brushes
- 1.
SYSNO ASEP 0487750 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Improving hemocompatibility of membranes for extracorporeal membrane oxygenators by grafting nonthrombogenic polymer brushes Tvůrce(i) Obstals, F. (DE)
Vorobii, M. (DE)
Riedel, Tomáš (UMCH-V) RID, ORCID
de los Santos Pereira, Andres (UMCH-V) RID, ORCID
Bruns, M. (DE)
Singh, S. (DE)
Rodriguez-Emmenegger, C. (DE)Číslo článku 1700359 Zdroj.dok. Macromolecular Bioscience. - : Wiley - ISSN 1616-5187
Roč. 18, č. 3 (2018), s. 1-11Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova ECMO ; hemocompatibility ; nonthrombogenic Vědní obor RIV BO - Biofyzika Obor OECD Biophysics CEP GBP205/12/G118 GA ČR - Grantová agentura ČR Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000426736000007 EID SCOPUS 85042940444 DOI https://doi.org/10.1002/mabi.201700359 Anotace Nonthrombogenic modifications of membranes for extracorporeal membrane oxygenators (ECMOs) are of key interest. The absence of hemocompatibility of these membranes and the need of anticoagulation of patients result in severe and potentially life-threatening complications during ECMO treatment. To address the lack of hemocompatibility of the membrane, surface modifications are developed, which act as barriers to protein adsorption on the membrane and, in this way, prevent activation of the coagulation cascade. The modifications are based on nonionic and zwitterionic polymer brushes grafted directly from poly(4-methyl-1-pentene) (TPX) membranes via single electron transfer-living radical polymerization. Notably, this work introduces the first example of well-controlled surface-initiated radical polymerization of zwitterionic brushes. The antifouling layers markedly increase the recalcification time (a proxy of initiation of coagulation) compared to bare TPX membranes. Furthermore, platelet and leukocyte adhesion is drastically decreased, rendering the ECMO membranes hemocompatible. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019
Počet záznamů: 1