Počet záznamů: 1
Synthesis, analysis and biological evaluation of new RGD mimetics
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SYSNO ASEP 0485824 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis, analysis and biological evaluation of new RGD mimetics Tvůrce(i) Balacheva, A. A. (BG)
Lambev, M. K. (BG)
Pashov, I. (BG)
Detcheva, R. L. (BG)
Sázelová, Petra (UOCHB-X) RID, ORCID
Momekov, G. Ts. (BG)
Kašička, Václav (UOCHB-X) RID, ORCID
Pajpanova, T. I. (BG)
Golovinsky, E. V. (BG)Zdroj.dok. Bulgarian Chemical Communications. - : Bulgarska Akademiya na Naukite - ISSN 0324-1130
Roč. 49, SI E (2017), s. 7-10Poč.str. 4 s. Akce Bulgarian Peptide Symposium /7./ Datum konání 10.06.2016 - 12.06.2016 Místo konání Blagoevgrad Země BG - Bulharsko Typ akce EUR Jazyk dok. eng - angličtina Země vyd. BG - Bulharsko Klíč. slova RGD ; biologically active peptides ; cytotoxicity Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000418303600002 Anotace The amino acid sequence L-arginyl-glycyl-L-aspartic acid (RGD) is a part of many extracellular proteins. It is a specific recognition site by integrins. Some synthetic RGD analogues bind specifically with integrin receptors on the cell membrane, which are over-expressed on the surface of various malignant human tumour and angiogenic endothelial cells. These peptides exert dual role by: inhibiting proliferation and migration of tumour cells and on the other hand by inhibiting angiogenesis. In recent years, many RGD cytotoxic agents have been developed, that showed promising results in vitro and in vivo. Herein we present the synthesis, analysis and biological evaluation of two new RGD analogues, modified in position 1 with Arg mimetics (Agb or Agp). Our pilot studies on their cytotoxicity were presented in comparison to parent RGD as standard. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2018
Počet záznamů: 1