Počet záznamů: 1
A revised timescale for human evolution based on ancient mitochondrial genomes
- 1.0485576 - ARÚB 2018 RIV GB eng J - Článek v odborném periodiku
Fu, Q. - Mittnik, A. - Johnson, P. L. F. - Bos, K. - Lari, M. - Bollongino, R. - Sun, Ch. - Giemsch, L. - Schmitz, R. - Burger, J. - Ronchitelli, A. M. - Martini, F. - Cremonesi, R. G. - Svoboda, Jiří - Bauer, P. - Caramelli, D. - Castellano, S. - Reich, D. - Pääbo, S. - Krause, J.
A revised timescale for human evolution based on ancient mitochondrial genomes.
Current Biology. Roč. 23, April 8 (2013), s. 553-559. ISSN 0960-9822. E-ISSN 1879-0445
Institucionální podpora: RVO:68081758
Klíčová slova: mitochondrial genome * human evolution * calibration
Obor OECD: Archaeology
Impakt faktor: 9.916, rok: 2013
Background: Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate that is approximately half that of previous estimates based on fossil calibration. This result has led to suggestions that major events in human evolution occurred far earlier than previously thought. Results: Here, we use mitochondrial genome sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration points for the mitochondrial clock, thus yielding a direct estimate of the mitochondrial substitution rate. Our clock yields mitochondrial divergence times that are in agreement with earlier estimates based on calibration points derived from either fossils or archaeological material. In particular, our results imply a separation of non-Africans from the most closely related sub-Saharan African mitochondrial DNAs (haplogroup L3) that occurred less than 62-95 kya. Conclusions: Though single loci like mitochondrial DNA (mtDNA) can only provide biased estimates of population divergence times, they can provide valid upper bounds. Our results exclude most of the older dates for African and non-African population divergences recently suggested by de novo mutation rate estimates in the nuclear genome.
Trvalý link: http://hdl.handle.net/11104/0281502
Počet záznamů: 1