Počet záznamů: 1
Huntington´s Disease - Molecular Pathogenesis and Current Models
- 1.
SYSNO ASEP 0483018 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Porcine Model of Huntington´s Disease Tvůrce(i) Rausová, Petra (UZFG-Y) RID, ORCID
Vochozková, Petra (UZFG-Y) ORCID
Vidinská, Daniela (UZFG-Y)
Hrnčiarová, Eva (UZFG-Y)
Bohuslavová, Božena (UZFG-Y) ORCID
Mačáková, Monika (UZFG-Y) RID
Valeková, Ivona (UZFG-Y) RID, ORCID
Juhás, Štefan (UZFG-Y) RID, ORCID
Ardan, Taras (UZFG-Y) RID, ORCID
Šolc, Petr (UZFG-Y) RID, ORCID
Motlík, Jan (UZFG-Y) RID, ORCID
Ellederová, Zdeňka (UZFG-Y) RID, ORCIDZdroj.dok. Huntington´s Disease - Molecular Pathogenesis and Current Models. - London : Intech, 2017 / Tunah N. E. - ISBN 978-953-51-3050-5 Rozsah stran s. 75-94 Poč.str. 20 s. Poč.výt. 1000 Poč.str.knihy 150 Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova large animal models ; pig ; huntingtin Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions (pharmacogenomics, gene-based therapeutics) CEP LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UZFG-Y - RVO:67985904 DOI https://doi.org/10.5772/66353 Anotace At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD). These minipigs express N‐terminal part of human mutated huntingtin including 124Q under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild‐type (WT) and transgenic (TgHD) piglets in all litters. We take different approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. In this chapter, we review these approaches and the phenotype progression in the minipigs. Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2018 Elektronická adresa https://www.intechopen.com/books/huntington-s-disease-molecular-pathogenesis-and-current-models/porcine-model-of-huntington-s-disease
Počet záznamů: 1