Počet záznamů: 1
Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
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SYSNO ASEP 0482594 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Transgenerational inheritance of susceptibility to diabetes-induced male subfertility Tvůrce(i) Pavlínková, Gabriela (BTO-N) RID, ORCID
Margaryan, Hasmik (BTO-N) RID
Žatecká, Eva (BTO-N)
Valášková, Eliška (BTO-N)
Elzeinová, Fatima (BTO-N) RID
Kubátová, Alena (BTO-N) RID
Bohuslavová, Romana (BTO-N) RID
Pěknicová, Jana (BTO-N) RIDCelkový počet autorů 8 Číslo článku 4940 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, JUL 10 2017 (2017)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova HIGH-FAT DIET ; MALE-INFERTILITY ; GENE-EXPRESSION ; SPERM PARAMETERS Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa Obor OECD Endocrinology and metabolism (including diabetes, hormones) CEP NV15-30880A GA MZd - Ministerstvo zdravotnictví GA16-06825S GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora BTO-N - RVO:86652036 UT WOS 000405180900013 EID SCOPUS 85034263302 DOI https://doi.org/10.1038/s41598-017-05286-0 Anotace Male infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of diabetic males. The study was performed in streptozotocin-induced type 1 diabetes mouse model. Diabetes decreased sperm concentration and viability and increased sperm apoptosis. Changes in protamine 1/protamine 2 ratio indicated reduced sperm quality. The testicular tissue of diabetic males showed significant tissue damage, disruption of meiotic progression, and changes in the expression of genes encoding proteins important for spermiogenesis. Paternal diabetes altered sperm quality and expression pattern in the testes in offspring of two subsequent generations. Our study revealed that paternal diabetes increased susceptibility to infertility in offspring through gametic alternations. Our data also provide a mechanistic basis for transgenerational inheritance of diabetes-associated pathologies since protamines may be involved in epigenetic regulations. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2018
Počet záznamů: 1