0477292 - ÚBO 2018 RIV GB eng J - Článek v odborném periodiku
Smith, P. - Willemsen, D. - Popkes, M. - Metge, F. - Gandiwa, E. - Reichard, Martin - Valenzano, D. R.
Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.
eLife. Roč. 6, e27014 (2017), č. článku e27014. ISSN 2050-084X. E-ISSN 2050-084X
Grant CEP: GA ČR(CZ) GA16-00291S
Institucionální podpora: RVO:68081766
Klíčová slova: Nothobranchius furzeri * Clostridium defficile infection * annual fishes
Obor OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impakt faktor: 7.616, rok: 2017

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a younglike gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.
Trvalý link: http://hdl.handle.net/11104/0273675