Počet záznamů: 1
The assembly and function of perinuclear actin cap in migrating cells
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SYSNO ASEP 0474654 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The assembly and function of perinuclear actin cap in migrating cells Tvůrce(i) Maninová, Miloslava (MBU-M) RID
Čáslavský, Josef (MBU-M)
Vomastek, Tomáš (MBU-M) RID, ORCIDZdroj.dok. Protoplasma - ISSN 0033-183X
Roč. 254, č. 3 (2017), s. 1207-1218Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. AT - Rakousko Klíč. slova LINC ; Stress fibers ; Focal adhesions Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA13-06405S GA ČR - Grantová agentura ČR Fellowship J. E. Purkyně GA AV ČR - Akademie věd Institucionální podpora MBU-M - RVO:61388971 UT WOS 000399037400008 EID SCOPUS 85009802402 DOI https://doi.org/10.1007/s00709-017-1077-0 Anotace Stress fibers are actin bundles encompassing actin filaments, actin-crosslinking, and actin-associated proteins that represent the major contractile system in the cell. Different types of stress fibers assemble in adherent cells, and they are central to diverse cellular processes including establishment of the cell shape, morphogenesis, cell polarization, and migration. Stress fibers display specific cellular organization and localization, with ventral fibers present at the basal side, and dorsal fibers and transverse actin arcs rising at the cell front from the ventral to the dorsal side and toward the nucleus. Perinuclear actin cap fibers are a specific subtype of stress fibers that rise from the leading edge above the nucleus and terminate at the cell rear forming a dome-like structure. Perinuclear actin cap fibers are fixed at three points: both ends are anchored in focal adhesions, while the central part is physically attached to the nucleus and nuclear lamina through the linker of nucleoskeleton and cytoskeleton (LINC) complex. Here, we discuss recent work that provides new insights into the mechanism of assembly and the function of these actin stress fibers that directly link extracellular matrix and focal adhesions with the nuclear envelope. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1