Počet záznamů: 1
Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications
- 1.
SYSNO ASEP 0473328 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications Tvůrce(i) Balaita, L. (RO)
Cadinoiu, A. N. (RO)
Postolache, P. (RO)
Šafaříková, Miroslava (UEK-B) RID, SAI
Popa, M. (RO)Celkový počet autorů 5 Zdroj.dok. Journal of Optoelectronics and Advanced Materials. - : NATL INST OPTOELECTRONICS - ISSN 1454-4164
Roč. 17, č. 7-8 (2015), s. 1198-1209Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. RO - Rumunsko Klíč. slova acid-modified chitosan ; drug-delivery ; nanoparticles ; release ; microparticles ; microspheres ; stability ; alcohol ; complex ; Chitosan ; Poly(vinyl alcohol) ; Magnetic particles ; Ionic crosslinking ; Covalent crosslinking ; Drug delivery Vědní obor RIV EH - Ekologie - společenstva Institucionální podpora RVO:67179843 - RVO:67179843 UT WOS 000359967600046 EID SCOPUS 84944261087 Anotace This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology. Pracoviště Ústav výzkumu globální změny Kontakt Nikola Šviková, svikova.n@czechglobe.cz, Tel.: 511 192 268 Rok sběru 2017
Počet záznamů: 1