Počet záznamů: 1
Optimizing Flow and Segregaton Properties of Lactose/Microcrystalline Cellulose Mixture for Tablet Compression.
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SYSNO ASEP 0472829 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV D - Článek ve sborníku Název Optimizing Flow and Segregaton Properties of Lactose/Microcrystalline Cellulose Mixture for Tablet Compression. Tvůrce(i) Zámostný, P. (CZ)
Kreibichová, B. (CZ)
Hofmanová, D. (CZ)
Kulaviak, Lukáš (UCHP-M) RID, ORCID, SAI
Zelenková, K. (CZ)
Růžička, Marek (UCHP-M) RID, ORCID, SAIZdroj.dok. Proceedings of the 3rd International Conference on Chemical Technology. - Prague : Czech Society of Industrial Chemistry, 2015 / Kalenda P. ; Lubojacký J. - ISBN 978-80-86238-82-1 Rozsah stran s. 478-483 Poč.str. 6 s. Forma vydání Online - E Akce ICCT International Conference on Chemical Technology Datum konání 13.04.2015-15.04.2015 Místo konání Mikulov Země CZ - Česká republika Typ akce EUR Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova segregation tests ; volumetric flow regime of transport ; mixing and compression Vědní obor RIV CI - Průmyslová chemie a chemické inženýrství Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000383856800092 Anotace The present study deals with optimizing the flow and segregation properties of levocetirizine hydrochloride formulation, where the delay between homogenization and tablet compression was found to affect the tablet content uniformity. In addition to API, the base formulation comprised spray dried lactose monohydrate, milled lactose monohydrate 200 mesh, Avicel PH 101 microcrystalline cellulose, and minor excipients. Several alternative mixtures were prepared using the same total composition, but different grades of lactose and microcrystalline cellulose. These mixtures were then tested for the segregation behavior in an in-house segregation device and the flow properties using the Freeman FT4 powder rheometer. The segregation tests showed the grade of lactose is essential for mixture in-flow segregation. While SD lactose mixtures increased the API content in a direction countercurrent to flow, the milled lactose mixtures segregated API concurrently. Mixtures using both lactose grades showed combined effect, resulting in the least segregation due to the two segregation processes competing with each other. However, the segregation was extremely sensitive to ageing of the mixture. It was also found that each type of lactose causes a different flow regime of the mixture in process vessels. In order to improve the content uniformity of the tablets, it was found the volumetric flow regime of transport to tablet press is required as well as the aggregate formation should be prevented.
Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2017 Elektronická adresa http://hdl.handle.net/11104/0270062
Počet záznamů: 1