Počet záznamů: 1
Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
- 1.
SYSNO ASEP 0466904 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs Tvůrce(i) Mokhodoeva, O. (RU)
Vlk, M. (CZ)
Málková, E. (CZ)
Kukleva, E. (CZ)
Mičolová, P. (CZ)
Štamberg, K. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Dzhenloda, R. (RU)
Kozempel, J. (CZ)Číslo článku 301 Zdroj.dok. Journal of Nanoparticle Research. - : Springer - ISSN 1388-0764
Roč. 18, č. 10 (2016), s. 1-12Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova magnetic nanoparticles ; radium ; sorption Vědní obor RIV CD - Makromolekulární chemie CEP NV16-30544A GA MZd - Ministerstvo zdravotnictví TE01020118 GA TA ČR - Technologická agentura ČR LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000388965800004 EID SCOPUS 84990941212 DOI https://doi.org/10.1007/s11051-016-3615-7 Anotace The use of superparamagnetic iron oxide nanoparticles (SPIONs) and radiolabelled nanoparticles (NPs) has grown considerably over the recent years, and the SPIONs labelled with medicinal radionuclides offer new opportunities in multimodal diagnostics and in the drug-delivery systems for targeted alpha-particle therapy (TAT) driven by magnetic field gradient or by biologically active moieties bound on NPs shell. However, the mechanisms of NPs radiolabelling are not studied substantially and still remain unclear, even though the way of label attachment directly implies the stability of the label-nanoparticle construct. Since the 223Ra was the first clinically approved alpha-emitter, it is a promising nuclide for further development of its targeted carriers. We report here on the study of 223Ra uptake by the Fe3O4SPIONs, together with an attempt to propose the 223Ra uptake mechanism by the Fe3O4NPs in the presence of a phosphate buffer a typical formulation medium, under the pseudo-equilibrium conditions. Further, the in vitro stability tests of the prepared [223Ra]Fe3O4NPs were performed to estimate the 223Ra label stability. The potential use of 223Ra-labelled SPIONs in theranostic applications is also discussed. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2017
Počet záznamů: 1