Počet záznamů: 1
Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination
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SYSNO ASEP 0465861 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination Tvůrce(i) Pelantová, Helena (MBU-M) ORCID, RID
Bugáňová, Martina (MBU-M)
Holubová, Martina (UOCHB-X) RID, ORCID
Šedivá, B. (CZ)
Zemenová, Jana (UOCHB-X)
Sýkora, D. (CZ)
Kaválková, P. (CZ)
Haluzík, M. (CZ)
Železná, Blanka (UOCHB-X) RID, ORCID
Maletínská, Lenka (UOCHB-X) RID, ORCID
Kuneš, Jaroslav (UOCHB-X) ORCID, RID
Kuzma, Marek (MBU-M) ORCID, RIDZdroj.dok. Molecular and Cellular Endocrinology. - : Elsevier - ISSN 0303-7207
Roč. 431, C (2016), s. 88-100Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova NMR metabolomics ; Mouse ; Obesity Vědní obor RIV EE - Mikrobiologie, virologie Vědní obor RIV – spolupráce Ústav organické chemie a biochemie - Endokrinologie, diabetologie, metabolizmus, výživa CEP GA13-14105S GA ČR - Grantová agentura ČR LO1509 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 ; UOCHB-X - RVO:61388963 UT WOS 000379276300009 EID SCOPUS 84971222599 DOI https://doi.org/10.1016/j.mce.2016.05.003 Anotace Metformin, vildagliptin and their combination are widely used for the treatment of diabetes, but little is known about the metabolic responses to these treatments. In the present study, NMR-based metabolomics was applied to detect changes in the urinary metabolomic profile of a mouse model of diet induced obesity in response to these treatments. Additionally, standard biochemical parameters and the expression of enzymes involved in glucose and fat metabolism were monitored. Significant correlations were observed between several metabolites (e.g., N-carbamoyl-beta-alanine, N1-methyl-4-pyridone-3-carboxamide, N1-methyl-2-pyridone-5-carboxamide, glucose, 3-indoxyl sulfate, dimethylglycine and several acylglycines) and the area under the curve of glucose concentrations during the oral glucose tolerance test. The present study is the first to present N-carbamoyl-beta-alanine as a potential marker of type 2 diabetes mellitus and consequently to demonstrate the efficacies of the applied antidiabetic interventions. Moreover, the elevated acetate level observed after vildagliptin administration might reflect increased fatty acid oxidation Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
Počet záznamů: 1