0460527 - ÚMCH 2017 RIV DE eng J - Článek v odborném periodiku
Lobaz, Volodymyr - Rabyk, Mariia - Pánek, Jiří - Doris, E. - Nallet, F. - Štěpánek, Petr - Hrubý, Martin
Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles.
Colloid and Polymer Science. Roč. 294, č. 7 (2016), s. 1225-1235. ISSN 0303-402X. E-ISSN 1435-1536
Grant CEP: GA MŠMT(CZ) 7AMB14FR027; GA ČR(CZ) GA13-08336S; GA MZd(CZ) NV15-25781A
Institucionální podpora: RVO:61389013
Klíčová slova: germanium oxide nanoparticles * polysaccharide coating * photoluminescent label
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 1.723, rok: 2016 ; AIS: 0.359, rok: 2016
DOI: https://doi.org/10.1007/s00396-016-3882-y

In current biomedically oriented research, the development of a biomimetic nanoparticle platform is of interest to provide a molecular toolbox (i.e., allowing easy modular exchange of its parts depending on actual needs while being nontoxic and allowing real-time recognition and tracking using various methods, such as fluorescence). We report the development of germanium(IV) oxide-polysaccharide composite particles possessing these properties. The nanoparticles are based on a crystalline germanium oxide core with a size range of 20–30 and 300–900 nm. Two new simple coating techniques were compared for the preparation of the photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles. The germanium(IV)-based core allows for in situ polysaccharide attachment via direct chelation. In addition, the nanoparticles were coated with thin layer of silicon oxide. After coating, 3-(triethoxysilyl)propyl isocyanate was grafted onto the surface, and the polysaccharides were immobilized on the particle surface via a covalent urethane linkage, which allows for an even more stable polysaccharide coating than that obtained via chelation. This approach provides access to a new material platform for biological track and image applications.
Trvalý link: http://hdl.handle.net/11104/0260807